Expanding Genomic Cancer Research
to Arab Populations

Cancer genomics research has historically focused on White European populations, creating a significant data gap for Arab communities. This limits the effectiveness of genetic screening and preventive care for these populations.

• Analyse genomic data from Saudi Arabian patients with familial cancers and their immediate family members

• Identify population-specific variants in known cancer genes which may be pathogenic

• Characterise familial cancer patterns

• Improve screening protocols within University hospitals

• Empower patients and healthcare providers by enabling proactive healthcare management

1. Data Analysis Framework

• Population-specific variant identification

• Statistical modelling of genetic distributions

• Comparative analysis with existing databases

• Risk assessment modelling

2. Technical Implementation

• Developed population-specific analysis pipelines

• Applied variant classification system and researched variants

• Presented statistics and evidenced novel associations with familial cancers

• Address reviewer comments on a related existing manuscript and apply statistical changes to increase robustness

3. Clinical Integration

• Healthcare provider guidance

• Publication of data to inform healthcare policy

Quantitative Outcomes

• Identified key variants associated with prostate, colorectal and breast cancer unique to Arab populations

• Mapped novel genetic patterns

• Published Research

• https://doi.org/10.3390/diagnostics13182993

• https://doi.org/10.18632/oncotarget.28457

Clinical Benefits

• More accurate risk assessment

• Improved preventive care options

• Better informed clinical decisions

• Enhanced family health planning

"UMBIZO was amazing to work with, very responsive and readily available for consultations. Their statistical abilities are top notch, as well as their technical expertise. The team was professional, courteous and provided quick feedback. They exceeded our expectations in expanding genetic research for Arab populations."

Dr. Malak Adbelgathari, Chair, Genomics Research Department,
Saudi Human Genome Lab

• Initial Analysis: 2 weeks

• Implementation and manuscript submission: 1 month

• Clinical Integration: 3 months

We have continued to work with this team on a second study. We look forward to expanding analysis to additional cancer types and developing more comprehensive screening protocols for diverse populations.